Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Downstream Processing01:29

Downstream Processing

Downstream processing begins once fermentation is complete and involves a series of steps to recover and purify products such as acids, vitamins, antibiotics, or proteins.Cell HarvestingFor example, for intracellular protein-based products, the first step is harvesting the cells. This is typically achieved using centrifugation or filtration to separate the cells from the liquid phase.Cell Disruption for Intracellular ProductsIf the target product is intracellular, the harvested cells must be...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Charge-Regulated Electrochemistry in Self-Standing Carbon Nanotube-Nanocellulose Hybrid Electrodes.

Langmuir : the ACS journal of surfaces and colloids·2026
Same author

Wnt4 as a signal coordinates DNA methylation and acetylation to determine germ line fate.

Developmental biology·2026
Same author

Engineering Disorder in Droplet Packings through Polydispersity and Adhesion.

ACS applied materials & interfaces·2026
Same author

Gut Microbiota-Derived Extracellular Vesicles in Patients With Obesity Undergoing Gastric Bypass Surgery.

Molecular microbiology·2026
Same author

Microfluidic Electro-Viscoelastic Separation of Submicron Particles and Extracellular Vesicles.

Analytical chemistry·2026
Same author

Thermoresponsive Reconfigurable Intelligent Electromagnetic Surfaces Enabled by VO<sub>2</sub> and Wood-Derived Nanocellulose, Suberin, and Biocarbon.

ACS applied bio materials·2026

Related Experiment Video

Updated: Jul 21, 2026

Membrane Remodeling of Giant Vesicles in Response to Localized Calcium Ion Gradients
08:15

Membrane Remodeling of Giant Vesicles in Response to Localized Calcium Ion Gradients

Published on: July 16, 2018

8.1K

Microfluidic electro-viscoelastic manipulation of extracellular vesicles.

Seyedamirhosein Abdorahimzadeh1,2, Éva Bozó1, Zikrullah Bölükkaya1

  • 1Disease Networks Research Unit, Faculty of Biochemistry and Molecular Medicine, University of Oulu, Finland.

FEBS Open Bio
|July 10, 2025
PubMed
Summary

This study introduces electro-viscoelastic microfluidics for manipulating extracellular vesicles (EVs). This novel method uses electric fields and fluid properties to control EV movement, showing promise for EV isolation.

Keywords:
electrokineticsextracellular vesiclesmicrofabricationmicrofluidicsviscoelasticity

More Related Videos

Mechano-Node-Pore Sensing: A Rapid, Label-Free Platform for Multi-Parameter Single-Cell Viscoelastic Measurements
05:49

Mechano-Node-Pore Sensing: A Rapid, Label-Free Platform for Multi-Parameter Single-Cell Viscoelastic Measurements

Published on: December 2, 2022

2.8K
Author Spotlight: Asymmetric Field Flow Fractionation for Bioreactor Integration
06:28

Author Spotlight: Asymmetric Field Flow Fractionation for Bioreactor Integration

Published on: February 2, 2024

896

Related Experiment Videos

Last Updated: Jul 21, 2026

Membrane Remodeling of Giant Vesicles in Response to Localized Calcium Ion Gradients
08:15

Membrane Remodeling of Giant Vesicles in Response to Localized Calcium Ion Gradients

Published on: July 16, 2018

8.1K
Mechano-Node-Pore Sensing: A Rapid, Label-Free Platform for Multi-Parameter Single-Cell Viscoelastic Measurements
05:49

Mechano-Node-Pore Sensing: A Rapid, Label-Free Platform for Multi-Parameter Single-Cell Viscoelastic Measurements

Published on: December 2, 2022

2.8K
Author Spotlight: Asymmetric Field Flow Fractionation for Bioreactor Integration
06:28

Author Spotlight: Asymmetric Field Flow Fractionation for Bioreactor Integration

Published on: February 2, 2024

896

Area of Science:

  • Biotechnology and Biomedical Engineering
  • Nanotechnology and Microfluidics

Background:

  • Microfluidic technology offers innovative tools for biological applications.
  • Extracellular vesicles (EVs) are significant in biological processes, driving research into effective isolation techniques.
  • Existing microfluidic methods for EV isolation require further development for efficiency and specificity.

Purpose of the Study:

  • To present electro-viscoelastic microfluidics as a novel approach for manipulating extracellular vesicles (EVs).
  • To demonstrate the potential of this system for developing advanced EV isolation tools.

Main Methods:

  • Development of an electro-viscoelastic microfluidic system.
  • Utilizing the viscoelastic properties of the suspending medium.
  • Applying an external electric field to influence EV motion within a microchannel.

Main Results:

  • The electro-viscoelastic microfluidic system successfully altered the motion of extracellular vesicles (EVs).
  • Demonstrated control over EV behavior through the combined effects of electric fields and viscoelasticity.
  • Validated the principle of electro-viscoelastic manipulation for micro-scale biological particles.

Conclusions:

  • Electro-viscoelastic microfluidics presents a promising new strategy for manipulating EVs.
  • The developed system has significant potential for future applications in EV isolation.
  • Further research and development could lead to optimized microfluidic devices for biomedical applications.