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Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence01:27

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Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
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Engineering Disorder in Droplet Packings through Polydispersity and Adhesion.

Indraja Sundara Raju1, Mostafa Bakouei1, Jonatan Mac Intyre1

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Summary

Researchers developed a microfluidic platform to control disorder in droplet systems for biomimetic design. This innovation allows tunable disorder, enabling new material development and patterned material exploration.

Keywords:
2D packingbiomimetic emulsionsbiotin−streptavidindisordered materialsdroplet microfluidics

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Area of Science:

  • Soft Matter Physics
  • Microfluidics
  • Materials Science

Background:

  • Disorder can be a tunable property for biomimetic design and material innovation.
  • Adapting controlled disorder principles from 2D materials to 2D microdroplet packings presents new opportunities.

Purpose of the Study:

  • To present a microfluidic platform for controlling disorder in droplet-based soft matter systems.
  • To investigate controlled disorder as a design parameter in 2D microdroplet packings.

Main Methods:

  • Developed a microfluidic platform integrating droplet generation, transfer, and imaging.
  • Optimized transfer channel height and employed air interface sweeping for reproducible 2D droplet packing.
  • Modulated droplet adhesion and polydispersity to engineer controlled disorder.

Main Results:

  • Demonstrated compact and reproducible 2D droplet packing using microfluidic engineering strategies.
  • Quantified structural disorder using bond orientational order parameters and excess entropy.
  • Validated that increased polydispersity and droplet adhesion lead to higher structural disorder.

Conclusions:

  • The microfluidic platform successfully engineers controlled disorder in 2D droplet packings.
  • This platform enables exploration of controlled disorder in patterned materials and biomimetic models.
  • The findings open avenues for material innovation by harnessing disorder as a tunable property.