Electrochemical 1,5-Aryl Migration for Stereo- and Regioselective Synthesis of Tetrasubstituted Alkenes
Xia-Die Wu1, Xian-Bing Luo1,2, Ru-Xi Hu1
1School of Pharmaceutical Sciences, Taizhou University, Jiaojiang Zhejiang, 318000, P. R. China.
Abstract:
An electrochemical 1,5-aryl migration protocol for the stereo- and regioselective synthesis of Se-containing tetrasubstituted α,β-unsaturated amides has been developed. This approach leverages readily available N-benzylpropiolamides and diselenides as starting materials and proceeds without the need for oxidants or metal reagents. The simplicity of the protocol is further enhanced by its execution in a straightforward undivided electrolytic cell at room temperature, providing an efficient and innovative route for the synthesis of challenging tetrasubstituted alkenes.
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