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Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
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Use of Human Perivascular Stem Cells for Bone Regeneration
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Bone regeneration using PRF, PRP and β-TCP in bone defects.

Vipin Arora1, Ankur Joshi2, Nishita Anthwal3

  • 1Department of Restorative Dental Sciences, Taif University, Kingdom of Saudi Arabia - 21944.

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|July 10, 2025
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Platelet-rich fibrin (PRF) significantly enhances bone regeneration compared to platelet-rich plasma (PRP) and beta-tricalcium phosphate (β-TCP). PRF demonstrated superior bone fill and density, highlighting its potential for effective bone healing.

Keywords:
Bone regenerationbeta-tricalcium phosphate (β-TCP)bone defectsosteogenesisplatelet-rich fibrin (PRF)platelet-rich plasma (PRP)

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Orthopedic Surgery

Background:

  • Bone defects require effective regeneration strategies.
  • Platelet concentrates and biomaterials are explored for bone healing.
  • Platelet-rich fibrin (PRF), platelet-rich plasma (PRP), and beta-tricalcium phosphate (β-TCP) are common regenerative materials.

Purpose of the Study:

  • To compare the efficacy of PRF, PRP, and β-TCP in promoting bone regeneration.
  • To evaluate bone fill and trabecular bone density in bone defects treated with these materials.

Main Methods:

  • Utilizing PRF, PRP, and β-TCP in experimental bone defects.
  • Assessing bone regeneration over a 12-week period.
  • Histological analysis to determine bone fill percentage and trabecular bone density.

Main Results:

  • PRF treatment resulted in the highest bone fill (85%) at 12 weeks.
  • PRP and β-TCP showed lower bone fill percentages (75% and 65%, respectively).
  • Histological findings indicated superior trabecular bone density in PRF-treated defects (p < 0.05).

Conclusions:

  • PRF promotes superior bone regeneration compared to PRP and β-TCP.
  • Sustained release of growth factors from PRF enhances bone tissue formation.
  • PRF shows significant potential as an effective biomaterial for clinical bone healing.