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Good's Syndrome Revealed by Recurrent Sigmoid Diverticulitis
Hassene Attout1, Jade Constant1, Amal Abdellatif1
1Internal Medicine Department, Les Cevennes Hospital, Alès, France.
European Journal of Case Reports in Internal Medicine
|July 10, 2025
Summary
Good's syndrome, an adult-onset immunodeficiency, is linked to thymoma and hypogammaglobulinaemia. This case highlights recurrent infections after thymectomy, emphasizing the need for vigilance in diagnosing this rare condition.
Area of Science:
- Immunology
- Oncology
- Infectious Disease
Background:
- The thymus is crucial for T lymphocyte education.
- Thymoma, a rare thymus neoplasm, is associated with autoimmune disorders like myasthenia gravis.
- Good's syndrome (GS) is an acquired immunodeficiency characterized by thymoma, hypogammaglobulinaemia, and recurrent infections.
Purpose of the Study:
- To report a case of recurrent sigmoid diverticulitis following thymectomy.
- To investigate the association between thymectomy, subsequent infections, and hypogammaglobulinaemia.
- To contribute to the understanding of thymoma-associated immunodeficiency.
Main Methods:
- Case report presentation.
- Clinical history review.
- Diagnostic workup for hypogammaglobulinaemia.
Main Results:
- A patient developed recurrent sigmoid diverticulitis post-thymectomy.
- Severe hypogammaglobulinaemia was identified in the patient.
- This case expands the spectrum of infections seen in thymoma-associated immunodeficiency.
Conclusions:
- Good's syndrome is a rare acquired immunodeficiency.
- Immunoglobulin replacement is the primary treatment for GS.
- This case underscores the complexity of thymoma-associated immune dysfunction.
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