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Clinically derived dose effect relationship for hyperthermia given in combination with low dose radiotherapy
The British Journal of Radiology
|March 1, 1985
Summary
High-frequency induced hyperthermia combined with radiotherapy shows an 86% response rate. Achieving higher tumor temperatures, above 42.5°C, is crucial for maximizing therapeutic effects in cancer treatment.
Area of Science:
- Oncology
- Medical Physics
- Radiotherapy Research
Background:
- Fractionated radiotherapy combined with hyperthermia is a treatment modality for various cancers.
- Optimizing hyperthermia parameters is essential for improving treatment efficacy.
Purpose of the Study:
- To retrospectively evaluate the relationship between tumor temperature and treatment response in patients receiving hyperthermia and radiotherapy.
- To identify temperature thresholds associated with complete and partial responses.
Main Methods:
- Retrospective analysis of 36 patients (44 treatment fields) receiving fractionated radiotherapy and local high-frequency induced hyperthermia.
- Evaluation of response rates (complete and partial) in relation to achieved tumor temperatures.
- Logistic analysis to determine the dose-effect relationship of tumor temperature.
Main Results:
- An overall response rate of 86% was achieved (14% complete, 73% partial).
- Higher tumor temperatures were observed in responders compared to non-responders.
- A significant positive correlation between tumor temperature and therapeutic effect was found, with a calculated 50% effective dose of 38.8°C.
Conclusions:
- Tumor temperature is a critical factor influencing the efficacy of combined hyperthermia and radiotherapy.
- Achieving tumor temperatures above 42.5°C is indicated for maximizing treatment response (>95% rate).
- Smaller tumors may have a higher probability of complete response.