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Updated: Sep 16, 2025

Synthesis of Esters Via a Greener Steglich Esterification in Acetonitrile
Published on: October 30, 2018
Design and synthesis of nigranoic acid esters as anti-inflammation agents
Chenliang Zhao1, Rensong Chen1, Mian Chen1
1Guizhou Key Laboratory of Miao Medicine, School of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang, China.
Abstract:
Nigranoic acid, an A ring-secocycloartene triterpenoid, was constantly found to possess various biological activities, including anti-inflammation. In this study, fifteen new nigranoic acid ester derivatives were synthesised in good yields and assessed for their anti-inflammation activities. As a result, all the compounds including nigranoic acid could reduce NO production considerably (p < 0.001) at a concentration of 50 μM except for compound 12. Among them, compound 7 showed more NO inhibition potency than others with a concentration of 9.7 μmol/mL and minimal cytotoxicity (cell viability: 100%) in RAW 264.7 cells. Moreover, compound 7 may regulate PTGS2 and NFE2L2 to affect its anti-inflammatory activity through the network pharmacology and molecular docking analysis, indicating its potential as an anti-inflammatory candidate.
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Nomenclature of Carboxylic Acid Derivatives: Amides and Nitriles
The IUPAC and common names of amides are derived from the parent carboxylic acid, by replacing the suffix “oic acid” and “ic acid,” respectively, with “amide.” In the following example, the IUPAC name ethanamide is derived from ethanoic acid, and the common name, acetamide, is obtained from acetic acid.