Related Experiment Video

Updated: Sep 16, 2025

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
07:26

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

Published on: July 18, 2017

11.9K

Exploring the intersection of atherosclerosis and Alzheimer's disease: the role of inflammation and complement

Emilia Vataja1, Giorgio Ratti2, Adrian Safa3

  • 1Department of Bacteriology and Immunology, University of Helsinki, Biomedicum 1 Haartmaninkatu 8, 00014, Helsinki, Finland.

Inflammation Research : Official Journal of the European Histamine Research Society ... [Et Al.]
|July 10, 2025
PubMed

Insights

Atherosclerosis and Alzheimer's disease share common risk factors and inflammatory pathways. Complement activation, a key immune response, plays a role in the pathology of both conditions.

Area of Science:

  • Neuroscience
  • Immunology
  • Cardiovascular Science

Background:

  • Atherosclerosis (AS) and Alzheimer's disease (AD) are complex, multifactorial conditions sharing numerous risk factors.
  • Co-occurrence of vascular dementia with AD is observed, and many AD cases exhibit cardiovascular disease markers.
  • Shared risk factors may promote chronic inflammation, including complement activation, at sites of vascular injury or molecular aggregate accumulation.

Purpose of the Study:

  • To investigate the potential links and shared mechanisms between Alzheimer's disease and Atherosclerosis.
  • To provide a comprehensive narrative review of the bridging points connecting AD and AS.

Main Methods:

  • A comprehensive narrative review was conducted.
  • Literature search focused on identifying shared pathophysiological mechanisms between AD and AS.

Main Results:

  • Inflammation serves as a critical connecting pathway between Alzheimer's disease and Atherosclerosis.
  • A significant link between systemic inflammation and neuroinflammation has been established.
  • Complement system activation, a central component of innate immunity, is implicated in the pathogenesis of both AD and AS.

Conclusions:

  • Atherosclerosis and Alzheimer's disease share overlapping pathophysiological mechanisms.
  • Inflammation and complement system activity are key commonalities in the development of both diseases.
Abstract

Keywords:
Cardiovascular diseaseComplementInflammationNeuroinflammation

More Related Videos

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology05:51

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

Published on: May 6, 2014

13.3K
Quantitative 3D In Silico Modeling q3DISM of Cerebral Amyloid-beta Phagocytosis in Rodent Models of Alzheimer's Disease09:33

Quantitative 3D In Silico Modeling q3DISM of Cerebral Amyloid-beta Phagocytosis in Rodent Models of Alzheimer's Disease

Published on: December 26, 2016

8.0K

Related Concept Videos

Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
92
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
41
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
41
Inflammation01:38

Inflammation

Overview
55.3K
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
675
Atherosclerosis IV: Nursing Management01:23

Atherosclerosis IV: Nursing Management

Nursing management for a patient with arteriosclerosis involves a comprehensive approach focusing on lifestyle modification, disease monitoring, education, and symptomatic care. Here is an overview of effective nursing strategies:Assessment and Monitoring: Initial and ongoing assessments are crucial. Nurses must document the patient's medical history, including any hypertension, diabetes, hyperlipidemia, and other cardiovascular diseases. Assessments also cover family history and lifestyle...
59