Related Experiment Video
Updated: Sep 16, 2025
06:27
Production of Near-Infrared Sensitive, Core-Shell Vaccine Delivery Platform
Published on: October 20, 2020
5.3K
Oral sustained release expandable dosage forms: innovations, challenges, and future directions.
Phool Chandra1, Sani Pratap Singh1, Vaibhav Rastogi1
1Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India.
Journal of Biomaterials Science. Polymer Edition
|July 10, 2025
Summary
Expandable drug delivery systems enhance oral therapy by expanding in the stomach for prolonged drug release. This review details mechanisms, materials, and applications of these innovative dosage forms.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery
- Biomaterials Science
Background:
- Oral sustained-release dosage forms improve patient compliance and therapeutic efficacy.
- Expandable drug delivery systems offer prolonged gastric retention and controlled drug release via size-based strategies.
Purpose of the Study:
- To provide a comprehensive review of expandable oral drug delivery systems.
- To highlight recent advancements and future directions in the field.
Main Methods:
- Review of key expandable mechanisms (swelling, unfolding, floating, mucoadhesion).
- Discussion of formulation strategies, polymeric materials, and in vivo behavior.
- Emphasis on smart polymers, 3D printing, and novel fabrication techniques.
Main Results:
- Expandable systems demonstrate potential for extended gastric residence time.
- Various mechanisms enable controlled drug release profiles.
- Recent innovations show promise for advanced manufacturing and applications.
Conclusions:
- Expandable dosage forms represent a significant advancement in oral drug delivery.
- Further research into smart polymers and fabrication techniques can optimize performance.
- These systems hold great potential for improving patient outcomes and treatment efficacy.
Keywords:
Expandable dosage formscontrolled drug deliverygastric retentionmucoadhesive drug delivery systemsoral sustained releaseswellable systemsMore Related Videos
Related Concept Videos
01:28Factors Influencing Drug Absorption: Pharmaceutical Parameters
197
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
197
01:22Drug Delivery: Miscellaneous Routes
471
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
471
01:18Drug Delivery: Enteral Route
747
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
747
01:16Drug Delivery: Overview
428
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
428
01:23Factors Affecting Dissolution: Particle Size and Effective Surface Area
1.0K
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
1.0K
01:20Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry
269
Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
269