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Updated: Sep 16, 2025

Synthesis and Purification of Iodoaziridines Involving Quantitative Selection of the Optimal Stationary Phase for Chromatography
Published on: May 16, 2014
Ir(III)-Photocatalyzed Stereoselective Synthesis of 2-Azadienes
Biprajit Paul1, Sayan Samanta1, Surajit Das1
1Department of Chemistry, Indian Institute of Technology Ropar, Nangal Road, Rupnagar, Punjab 140001, India.
Abstract:
A photocatalyzed, stereoselective C-N bond formation reaction was developed to synthesize 2-azadiene scaffolds containing trifluoromethyl groups under mild reaction conditions. This current methodology employs the multitasking photocatalysis of fac-Ir(ppy)3 to generate iminyl radicals from bench-stable oxime-ester precursors via an energy transfer (EnT) mechanism. This iminyl radical is installed in the olefinic system as an N-linchpin without any prefunctionalization through a photoredox cycle. The advantages of the reaction consist of mild aerobic reaction conditions, broad scopes, high yield, and impressive stereoselectivity.
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