Study on TGF beta polymorphism in psoriatic patients with plaques infected with Streptococcuspyogenes

Immune control and skin homeostasis depend on transforming growth factor-beta 1 (TGF-β1), which also may affect pathogenesis of psoriasis. Using MLVA typing, this study looked at the relationship between TGF-β1 509 C/T polymorphism and psoriasis susceptibility in an Iranian population as well as related Streptococcus pyogenes strains. Enrolled were fifty psoriatic patients overall as well as fifty matched healthy controls. Tetra Arms PCR was used for the extraction and analysis of genomic DNA; bacterial strain identification was achieved with MLVA. Though the TT genotype displayed a higher odds ratio (OR: 1.222), the relationship with psoriasis was not statistically significant (p = 0.779). Case and control T and C allele frequencies were rather similar. Out of all the patients, 18 % showed early-onset psoriasis. Of the nineteen bacterial isolates, SPY1 and SPY3 turned out as main markers. These results imply a possible but unproven involvement of TGF-β1 polymorphism in psoriasis susceptibility. It is advised further study using bigger samples.