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Updated: Sep 16, 2025
Sleeve Gastrectomy in Mice using Surgical Clips
Published on: November 14, 2020
Impact of weight loss on epicardial adipose tissue after laparoscopic sleeve gastrectomy: a CT-based quantitative
Peng Ronggang1, Meng Weilun2, Du Lei3
1Department of Cardiology, Affiliated Hospital of Jiangnan University, Wuxi, China.
Background:
Bariatric surgery is an effective method for weight reduction, and epicardial adipose tissue (EAT) is a recognized marker of cardiovascular disease risk. However, the impact of weight loss on EAT and the correlation between reduced body weight and changes in EAT remain unclear.
Objective:
This study examines the impact of weight loss following laparoscopic sleeve gastrectomy (LSG) on EAT volume and its correlation with body mass index (BMI) reduction.
Setting:
This study was conducted at 2 hospitals in China: the Affiliated Hospital of Jiangnan University and Shanghai 10th People's hospital.
Method:
Consecutive patients who underwent LSG were screened for inclusion between August 2016 and December 2024. EAT parameters were assessed both preoperatively and 12 months postsurgery using the ITK-SNAP CT imaging technique. Additionally, indicators of cardiac structure and function were collected.
Results:
A total of 88 patients were included. After 12 months, significant reductions were observed in EAT volume (402.73 ± 52.80 ml to 372.14 ± 51.70 ml, P < .001), left atrial diameter (LAD; 37.66 ± 3.70 mm to 35.03 ± 3.65 mm, P < .001), interventricular septum thickness (IVS; 10.18 ± .94 mm to 9.52 ± .88 mm, P < .001), and left ventricular mass (LVmass; 262.27 ± 59.59 g to 235.55 ± 47.99 g, P < .001). No significant changes were observed in left ventricular ejection fraction (LVEF; 64.43 ± 5.00% to 65.35 ± 3.03%, P = .084). Moreover, changes in BMI were positively correlated with changes in EAT (r = .509, P < .001), LAD (r = .219, P = .040), and IVS (r = .262, P = .014).
Conclusion:
Significant improvement in EAT and cardiac structural remodeling occurs after LSG surgery, which strongly correlates with BMI reduction. EAT serves as a novel mediator in the relationship between obesity and cardiovascular disease, and bariatric surgery has the potential to mitigate cardiovascular risk by targeting this therapeutic focus.
