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Published on: November 5, 2019
Modeling antibody persistence after MenACYW-TT vaccination and comparative analysis with other quadrivalent
Laurent Coudeville1, Isabelle Bertrand-Gerentes2, Céline Zocchetti2
1Global Medical, Sanofi Vaccines, 14 Espace. Henry Vallée, 69007, Lyon, France. Laurent.Coudeville@sanofi.com.
Abstract:
Evaluating the persistence of antibody titers produced by quadrivalent meningococcal vaccines is crucial for determining the optimal timing for primary and booster doses. Using 3 - 7-year persistence data after a single priming dose of MenACYW-TT to fit a statistical model of antibody decay over time (10 years), this analysis modeled long-term antibody persistence for this vaccine in toddlers (12-23 months), adolescents/young adults (13-26 years), and older adults (≥ 56 years), comparing it with other vaccines (MCV4-TT, MenACWY-CRM, MPSV4). The statistical model is based on a Bayesian approach and it accounts for vaccine- and age group-specific antibody decline, missing data, assay errors, and antibody boosting from breakthrough infections. At 10 years post-vaccination, it predicted comparable or higher seroprotective immunopersistence for MenACYW-TT (titers ≥ 1:8 with hSBA) versus (1) MCV4-TT in toddlers (77% [95% CI 70-84] vs. 17% [6-31] for serogroup C, 67% [59-74] vs. 36% [20-53] for serogroup W); (2) MenACWY-CRM in adolescents/young adults (63% [55-71] vs. 40% [32-48] for serogroup C, 67% [59-74] vs. 57% [47-67] for serogroup W); and (3) MPSV4 in older adults (31% [23-39] vs. 22% [14-29] for serogroup C, 38% [31-46] vs. 20% [14-27] for serogroup W). In conclusion, our analysis indicated similar or higher immune persistence at 10 years for MenACYW-TT compared with other quadrivalent meningococcal vaccines, particularly for serogroups C and W.
Insights
This study modeled long-term antibody persistence for the quadrivalent meningococcal vaccine MenACYW-TT. Results show comparable or higher immunopersistence at 10 years compared to other vaccines, especially for serogroups C and W.
Area of Science:
- Immunology
- Vaccinology
- Epidemiology
Background:
- Determining optimal meningococcal vaccine dosing requires understanding antibody titer persistence.
- Quadrivalent meningococcal vaccines (MenACYW) are critical for preventing invasive meningococcal disease.
Purpose of the Study:
- To model and predict long-term antibody persistence of the MenACYW-TT vaccine up to 10 years post-vaccination.
- To compare the immunopersistence of MenACYW-TT with other quadrivalent meningococcal vaccines (MCV4-TT, MenACWY-CRM, MPSV4) across different age groups.
Main Methods:
- Utilized 3-7 year persistence data from a single priming dose of MenACYW-TT to develop a Bayesian statistical model.
- The model accounts for age-specific antibody decline, missing data, assay errors, and boosting from breakthrough infections.
- Predicted antibody titers (≥1:8 with hSBA) at 10 years post-vaccination for toddlers, adolescents/young adults, and older adults.
Main Results:
- At 10 years, MenACYW-TT demonstrated comparable or higher seroprotective immunopersistence versus MCV4-TT in toddlers for serogroups C and W.
- MenACYW-TT showed higher immunopersistence than MenACWY-CRM in adolescents/young adults for serogroup C and comparable persistence for serogroup W.
- Compared to MPSV4 in older adults, MenACYW-TT predicted higher immunopersistence for both serogroup C and W at 10 years.
Conclusions:
- The MenACYW-TT vaccine exhibits similar or superior immune persistence at the 10-year mark compared to other quadrivalent meningococcal vaccines.
- These findings support the sustained protective immunity offered by MenACYW-TT, particularly against serogroups C and W.
- The study provides valuable insights for optimizing vaccination schedules and strategies for meningococcal disease prevention.
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