AI generations: from AI 1.0 to AI 4.0
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Updated: Nov 9, 2025

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Jiahao Wu1, Hengxu You1, Jing Du1
1Informatics, Cobots and Intelligent Construction Lab, Engineering School of Sustainable Infrastructure and Environment, University of Florida, Gainesville, FL, United States.
Abstract:
This paper proposes that Artificial Intelligence (AI) progresses through several overlapping generations: AI 1.0 (Information AI), AI 2.0 (Agentic AI), AI 3.0 (Physical AI), and a speculative AI 4.0 (Conscious AI). Each AI generation is driven by shifting priorities among algorithms, computing power, and data. AI 1.0 accompanied breakthroughs in pattern recognition and information processing, fueling advances in computer vision, natural language processing, and recommendation systems. AI 2.0 is built on these foundations through real-time decision-making in digital environments, leveraging reinforcement learning and adaptive planning for agentic AI applications. AI 3.0 extended intelligence into physical contexts, integrating robotics, autonomous vehicles, and sensor-fused control systems to act in uncertain real-world settings. Building on these developments, the proposed AI 4.0 puts forward the bold vision of self-directed AI capable of setting its own goals, orchestrating complex training regimens, and possibly exhibiting elements of machine consciousness. This paper traces the historical foundations of AI across roughly 70 years, mapping how changes in technological bottlenecks from algorithmic innovation to high-performance computing to specialized data have stimulated each generational leap. It further highlights the ongoing synergies among AI 1.0, 2.0, 3.0, and 4.0, and explores the ethical, regulatory, and philosophical challenges that arise when artificial systems approach (or aspire to) human-like autonomy. Ultimately, understanding these evolutions and their interdependencies is pivotal for guiding future research, crafting responsible governance, and ensuring that AI's transformative potential benefits society.
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