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B-Cell Lymphoma Presenting as a Pancreatic Mass
Sondos Badran1, Alexander T Phan1, Adelle Kanan2
1Department of Internal Medicine, Arrowhead Regional Medical Center, Colton, CA 92324, USA.
Journal of Medical Cases
|July 11, 2025
Summary
This case highlights a rare instance of high-grade B-cell lymphoma presenting as pancreatic mass, causing obstructive jaundice and pancreatitis. It underscores the importance of considering lymphoma in unusual abdominal presentations.
Area of Science:
- Oncology
- Gastroenterology
- Pathology
Background:
- Non-Hodgkin lymphoma (NHL) encompasses diverse subtypes, with diffuse large B-cell lymphoma being the most prevalent.
- Typical NHL symptoms include lymphadenopathy, fever, night sweats, and weight loss.
- Treatment strategies for NHL are subtype-dependent.
Observation:
- A patient presented with obstructive jaundice and pancreatitis, atypical symptoms for NHL.
- Abdominal imaging revealed a pancreatic mass.
- Biopsy confirmed high-grade B-cell lymphoma.
Findings:
- The pancreatic mass was diagnosed as high-grade B-cell lymphoma.
- This represents a rare case of likely primary pancreatic lymphoma.
- The presentation deviated significantly from typical NHL symptomatology.
Implications:
- This case expands the differential diagnosis for pancreatic masses.
- It emphasizes the need for thorough investigation in atypical presentations of lymphoma.
- Early and accurate diagnosis is crucial for appropriate management of rare pancreatic malignancies.
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