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Prognostic Value of Albumin-To-Fibrinogen Ratio and Fibrinogen and Albumin Score in Lung Cancer Patients: A
Zongyuan Li1,2, Yueli Shu1, Wenying Xu3
1Department of Thoracic Surgery and Institute of Thoracic Oncology, West China Hospital, Sichuan University, Chengdu, China.
Background:
We aim to comprehensively assess the prognostic performance of AFR and FA scores in patients with lung cancer (LC).
Methods:
We conducted a comprehensive search of PubMed, Web of Science, and CNKI databases to identify relevant studies. The primary endpoints assessed were overall survival (OS) and progression-free survival (PFS). Integrated hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated through pooling analysis.
Results:
A total of 3145 participants from 10 studies were included in the analysis. In LC patients, the pooled results showed that low AFR predicted a worse outcome for OS (HR 1.76, 95% CI 1.51-2.06, p < 0.001) and PFS (HR 1.50, 95% CI 1.29-1.74, p < 0.001), and high FA score was associated with worse OS (HR 2.61, 95% CI 1.75-3.90, p < 0.001) and PFS (HR 2.38, 95% CI 1.60-3.55, p < 0.001).
Conclusion:
This meta-analysis demonstrated that a low AFR and a high FA score were associated with an increased risk of mortality and disease progression in LC, suggesting their potential as prognostic biomarkers.
