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Post-COVID-19 Neurocognitive Screening in Routine Pilot Aeromedical Evaluations.

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Updated: Sep 16, 2025

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
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Appropriate Screening Tests to Assess Post-COVID-19 Cognitive Dysfunction in Aeromedical Settings.

Solomon G Beka, Robin F Griffiths, Julia A Myers

    Aerospace Medicine and Human Performance
    |July 11, 2025
    PubMed
    Summary

    Post-COVID-19 cognitive dysfunction affects pilots. The Trail Making Test and Symbol Digit Modalities Test are recommended as quick, suitable screening tools for aeromedical evaluations.

    Keywords:
    aeromedical evaluationslong COVIDneurocognitive screening tests

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    Area of Science:

    • Aviation Medicine
    • Neuropsychology
    • Aerospace Medicine

    Background:

    • 10-20% of individuals experience long-term post-COVID-19 symptoms, including cognitive deficits.
    • Cognitive dysfunction can impact pilot performance, necessitating sensitive screening.
    • Identifying effective cognitive screening tools is crucial for aviation safety.

    Purpose of the Study:

    • To identify appropriate screening tests for post-COVID-19 cognitive dysfunction in pilots.
    • To evaluate the suitability of cognitive screening tools for aeromedical settings.

    Main Methods:

    • Systematic literature review identified 13 potential screening tools.
    • Five tests were selected for a modified Delphi evaluation with experts.
    • Consensus was reached on tests suitable for screening pilots.

    Main Results:

    • The Trail Making Test and Symbol Digit Modalities Test were identified as suitable.
    • These tests are quick, objective, and relevant to pilot cognitive skills.
    • Expert consensus supported their use for post-COVID-19 cognitive screening.

    Conclusions:

    • The Trail Making Test and Symbol Digit Modalities Test are recommended for screening pilots.
    • These tools assess relevant cognitive abilities and have good utility.
    • Further validation for detecting COVID-19 related neurocognitive impacts is suggested.