Characterizing changes in functioning in Brazilian patients with ALS using a comprehensive ICF core set

Area of Science:

• Neurology
• Rehabilitation Medicine
• Health Sciences

Background:

• Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease impacting motor function.
• Understanding the longitudinal impact of ALS on daily functioning is crucial for patient care and rehabilitation.
• The International Classification of Functioning, Disability and Health (ICF) provides a framework for assessing disability.

Purpose of the Study:

• To longitudinally describe the impact of amyotrophic lateral sclerosis (ALS) on functioning and disability.
• To utilize a core set of 42 ICF categories to assess changes over time.
• To identify key areas affected by ALS for guiding rehabilitation.

Main Methods:

• 42 Brazilian patients with ALS were assessed over 16 months.
• Assessments were conducted at baseline and every six months using 42 ICF categories.
• Statistical analyses included Friedman test and Wilcoxon post hoc tests with Bonferroni correction.

Main Results:

• Significant changes were observed in 24 out of 42 ICF categories.
• Key affected body functions included respiratory muscle function, muscle power, and gait.
• Limitations in activities and participation involved transferring, hand/arm use, dressing, washing, and speaking.

Conclusions:

• The developed ICF core set effectively captures the longitudinal impact of ALS.
• This core set can identify facilitators and barriers to functioning and disability in ALS patients.
• Findings can inform and guide targeted rehabilitation interventions for individuals with ALS.