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Consistency Analysis of Centiloid Values Across Three Commercial Software Platforms for Amyloid PET Quantification
Hyukjin Yoon1, Narae Lee1, Yoo Hyun Um2
1Division of Nuclear Medicine, Department of Radiology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul 06591, Republic of Korea.
Diagnostics (Basel, Switzerland)
|July 12, 2025
Summary
Three commercial software platforms show high consistency in calculating Centiloid (CL) values for amyloid PET imaging. However, a systematic bias exists, necessitating further research for improved reproducibility in clinical practice.
Area of Science:
- Neuroimaging
- Nuclear Medicine
- Radiochemistry
Background:
- Amyloid PET imaging is crucial for diagnosing Alzheimer's disease.
- Centiloid (CL) quantification standardizes amyloid PET results.
- Commercial software platforms are increasingly used for CL calculations.
Purpose of the Study:
- To evaluate the consistency of Centiloid (CL) values.
- To compare three commercial software platforms: BTXBrain, MIM, and SCALE PET.
- To identify potential biases in CL quantification.
Main Methods:
- Retrospective analysis of 239 amyloid PET/CT scans (F-18 flutemetamol or F-18 florbetaben).
- CL values computed using BTXBrain, MIM, and SCALE PET.
- Statistical analyses included linear regression, Passing-Bablok, and Bland-Altman.
Main Results:
- Strong correlations (R² > 0.95) were found between the software platforms.
- Significant proportional bias was detected, with BTXBrain yielding lower and SCALE PET yielding higher CL values.
- Bland-Altman plots confirmed systematic bias, especially between BTXBrain and SCALE PET.
Conclusions:
- Commercial software demonstrates high consistency in CL quantification.
- A notable systematic bias exists between platforms.
- Further research on scanner effects and calculation methods is needed for clinical reproducibility.
