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Updated: Sep 16, 2025

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Photopolymer Flexographic Printing Plate Mold for PDMS Microfluidic Manufacture.

Ana Belén Peñaherrera-Pazmiño1, Gustavo Iván Rosero2, Maximiliano Pérez2,3,4

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Summary

Flexographic printing plate molds (FMold) offer a cost-effective and scalable method for fabricating microfluidic devices. This technology enables rapid prototyping for diverse applications in cell culture, drug screening, and diagnostics.

Keywords:
biomedicinecell cultureflexographymicrofluidicssustainable development goal 10sustainable development goal 3

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Area of Science:

  • Materials Science
  • Biotechnology
  • Engineering

Background:

  • Flexographic printing, a technique from the packaging industry, is being adapted for microfluidic device fabrication.
  • Traditional microfluidic fabrication methods are often costly and time-consuming.
  • Photopolymer flexographic printing plate molds (FMold) present a low-cost, high-resolution alternative.

Purpose of the Study:

  • To review the adaptation of FMold for microfluidic applications.
  • To examine the advantages, challenges, and diverse applications of FMold in microfluidics.
  • To provide a state-of-the-art overview of FMold technology in microfluidic systems.

Main Methods:

  • Review of scientific literature on FMold for microfluidics since its inception in 2018.
  • Analysis of 50 publications utilizing FMold across various research laboratories.
  • Identification of key advancements, research trends, and future prospects.

Main Results:

  • FMold enables cost-effective, scalable, and rapid prototyping of microfluidic devices.
  • Applications include rock-on-a-chip models, droplet generation, cell culture, antibody production, drug screening, and diagnostics.
  • FMold has been adopted in 50 publications globally, demonstrating its growing impact.

Conclusions:

  • FMold is a versatile and accessible technology for microfluidic device fabrication.
  • Its advantages in cost, scalability, and prototyping speed make it suitable for a wide range of scientific and diagnostic applications.
  • Continued research and development are expected to further expand the capabilities and applications of FMold in microfluidics.