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Related Experiment Video

Updated: Sep 16, 2025

Bioprintable Alginate/Gelatin Hydrogel 3D In Vitro Model Systems Induce Cell Spheroid Formation
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3D-Printed Alginate-Based Hydrogels with Appropriate Rheological Properties and Efficient Development of Cell

Alida Mazzoli1, Stefania Greco2, Francesca Luzi1

  • 1Department of Science and Engineering of Matter, Environment and Urban Planning (SIMAU), Università Politecnica delle Marche, UdR INSTM, Via Brecce Bianche, 60131 Ancona, Italy.

Polymers
|July 12, 2025
PubMed
Summary
This summary is machine-generated.

Researchers developed a novel 3D-printable hydrogel bioink from sodium alginate. This biocompatible material offers structural integrity for cell-laden hydrogel printing, supporting tissue engineering and regenerative medicine applications.

Keywords:
3D bioprintingbio inkcell growthcell laden hydrogelregenerative medicinerheology

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Bioprinting Technology

Background:

  • Advancements in bioprinting necessitate innovative bioinks for creating functional cell-laden hydrogel structures.
  • The properties of bioinks are critical for achieving structural integrity and cell viability post-printing.

Purpose of the Study:

  • To develop a 3D-printable hydrogel using a natural, biocompatible polymer for tissue engineering applications.
  • To optimize a bioink formulation based on sodium alginate for extrusion bioprinting.

Main Methods:

  • Utilized sodium alginate cross-linked with calcium ions to create a printable hydrogel.
  • Employed the Cellink INKREDIBLE+ printer for fabricating 3D structures.
  • Characterized the morphology of 3D spheroids using light microscopy, fluorescent microscopy, and field emission scanning electron microscopy (FESEM).

Main Results:

  • Successfully produced 3D structures using the lab-formulated bioink.
  • The developed bioink demonstrated suitable viscosity for extrusion printing and maintained structural integrity.
  • Morphological characterization confirmed the viability and structure of the printed 3D spheroids.

Conclusions:

  • The developed sodium alginate-based hydrogel exhibits promising properties for 3D cell culture applications.
  • The bioink's characteristics suggest potential utility as a scaffold in regenerative medicine and research.
  • This biocompatible hydrogel offers a viable framework for advanced tissue engineering constructs.