Related Experiment Video
Updated: Jun 13, 2026
10:09
Fabricating Reactive Surfaces with Brush-like and Crosslinked Films of Azlactone-Functionalized Block Co-Polymers
Published on: June 30, 2018
8.4K
Development and Characterization of Self-Adhesive Polymeric Films with Antiallergic Effect
Ioana Savencu1, Sonia Iurian1, Cătălina Bogdan2,3
1Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
Polymers
|July 12, 2025
Summary
Researchers developed novel self-adhesive films containing diphenhydramine hydrochloride (DPH) for antiallergic treatment. These films demonstrated good mechanical properties and drug release, potentially improving patient adherence to topical therapies.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
- Drug Delivery
Background:
- Topical antiallergic treatments often face challenges with patient adherence.
- Self-adhesive films offer a promising alternative for localized drug delivery.
- Diphenhydramine hydrochloride (DPH) is a common active pharmaceutical ingredient (API) for treating allergic reactions.
Purpose of the Study:
- To design and optimize self-adhesive cutaneous films with an antiallergic effect.
- To investigate the impact of formulation variables on film properties and drug release.
- To develop a novel drug delivery system for enhanced patient compliance.
Main Methods:
- Design of Experiments (DOE) approach utilizing a full factorial design.
- Formulation of self-adhesive films using polyvinyl alcohol (PVA), polyacrylic acid (PAA), and plasticizers.
- Characterization of mechanical properties (hardness, deformation), adhesive force, and in vitro DPH release.
- Analysis of API distribution using Raman spectroscopy.
Main Results:
- Polyvinyl alcohol (PVA) ratio significantly influenced film properties and drug release.
- Optimized films exhibited favorable mechanical strength (hardness: 463.7 g, deformation: 16.56 mm) and adhesion (76 g).
- In vitro studies showed up to 68% DPH release over 12 hours, with API distributed in film layers.
Conclusions:
- A novel self-adhesive film formulation for topical antiallergic treatment was successfully developed.
- The optimized film demonstrates suitable properties for effective drug delivery and patient use.
- This innovative approach has the potential to improve adherence to local antiallergic therapies.
