Related Experiment Video
Updated: Sep 16, 2025
07:13
Implantation of Tissue-Engineered Vascular Graft in Mouse Carotid Artery via Cuff Technique
Published on: May 2, 2025
406
Novel Magnetically Charged Grafts for Vascular Repair: Process Optimization, Mechanical Characterization and In Vitro
Iriczalli Cruz-Maya1, Roberto De Santis1, Luciano Lanotte1,2
1Institute of Polymers, Composites and Biomaterials (IPCB), National Research Council of Italy, Mostra d'Oltremare Pad. 20, V.le J. F. Kennedy 54, 80125 Naples, Italy.
Polymers
|July 12, 2025
Summary
Nickel-based magnetic nanoparticles (MNPs) were incorporated into electrospun vascular grafts using two polymers. These novel nanocomposite grafts show potential for vascular disease treatment without harming cell viability.
Area of Science:
- Biomaterials Engineering
- Nanotechnology
- Vascular Surgery
Background:
- Magnetic nanoparticles (MNPs) offer non-invasive diagnostic and therapeutic potential for vascular diseases.
- Electrospinning is a viable technique for fabricating vascular grafts.
Purpose of the Study:
- To optimize novel vascular grafts loaded with Nickel-based MNPs using electrospinning.
- To evaluate the properties and in vitro performance of these nanocomposite grafts.
Main Methods:
- Fabrication of 3D electrospun nanocomposite grafts using Corethane A80 (COT) and Chronoflex AL80 (CHF) polymers with MNPs.
- Characterization using Scanning Electron Microscopy (SEM), Thermogravimetric Analysis (TGA), Differential Scanning Calorimetry (DSC), and mechanical testing.
- In vitro cell viability assessment over 7 days.
Main Results:
- SEM confirmed homogeneous fiber distribution, with MNPs reducing diameter variations.
- TGA indicated better MNP entrapment in CHF (18.25%) compared to COT (14.63%).
- Mechanical tests showed a decrease in strength upon MNP addition, varying by polymer matrix.
- In vitro studies demonstrated no negative impact on cell viability after 7 days.
Conclusions:
- Electrospun nanocomposite vascular grafts incorporating MNPs are feasible.
- The materials show promise for smart vascular grafts supporting vessel wall muscle actuation.
- Further research is warranted for clinical applications in vascular disease treatment.
