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Updated: Sep 16, 2025

Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model
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Combining Self-Reported Information with Radiographic Bone Loss to Screen Periodontitis: A Performance Study.

José João Mendes1, Margarida Neves1, Clara Supiot1

  • 1Egas Moniz Center for Interdisciplinary Research (CiiEM), Egas Moniz School of Health & Science, 2829-511 Almada, Portugal.

Journal of Clinical Medicine
|July 12, 2025
PubMed
Summary
This summary is machine-generated.

This study found that combining self-reported periodontal health information with radiographic bone loss effectively screens for periodontitis. This dual approach offers a practical method for identifying at-risk individuals when full exams aren

Keywords:
oral healthperiodontal diseaseperiodontitisprediction modelradiographic periodontal bone lossself-report

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Area of Science:

  • Periodontology
  • Diagnostic Accuracy
  • Public Health Screening

Background:

  • Periodontitis is a prevalent oral disease requiring effective screening methods.
  • Current screening may not be universally accessible or feasible.
  • Evaluating combined diagnostic approaches is crucial for early detection.

Purpose of the Study:

  • To assess the diagnostic performance of combined self-reported periodontal data and radiographic periodontal bone loss (R-PBL) for periodontitis identification.
  • To compare the efficacy of individual and combined screening indicators.

Main Methods:

  • An exploratory cross-sectional study involving 150 adult participants.
  • Utilized panoramic radiographs for R-PBL assessment and a validated self-reported questionnaire.
  • Analyzed screening performance against the 2018 periodontitis case definition using sensitivity, specificity, PPV, NPV, and AUC.

Main Results:

  • The R-PBL model showed the highest predictive performance for periodontitis (AUC: 0.833) and severe periodontitis (AUC: 0.796).
  • The combined 'Either' model demonstrated comparable sensitivity to R-PBL.
  • Decision curve analysis indicated superior clinical utility for 'R-PBL' and 'Either' models.

Conclusions:

  • Combining self-reported information with radiographic bone loss provides adequate screening performance for periodontitis.
  • This dual screening strategy is a feasible approach for identifying high-risk individuals, especially in resource-limited settings.
  • The findings support the integration of these methods for improved periodontitis detection and management.