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Cyclodextrin-Based Quercetin Powders for Potential Nose-to-Brain Transport: Formulation and In Vitro Assessment

Elmina-Marina Saitani1, Paraskevi Papakyriakopoulou1, Theodora Bogri1

  • 1Section of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece.

Molecules (Basel, Switzerland)
|July 12, 2025
PubMed
Summary

Spray-dried quercetin (Que) nasal powders using hydroxypropyl-β-cyclodextrin (HPβCD) show enhanced delivery. Formulation optimization with excipients like HPMC and MLMPs can tailor physicochemical properties for improved nose-to-brain drug delivery.

Keywords:
cyclodextrinsfreeze-dryingin vitro diffusion experimentsnasal powdersquercetinscanning electron microscopyspray-dryingthermogravimetric analysis

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