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Related Concept Videos

Scanning Electron Microscopy01:07

Scanning Electron Microscopy

A scanning electron microscope (SEM) is used to study the surface features of a sample by using an electron beam that scans the sample surface in a two-dimensional manner. Typically, areas between ~1 centimeter to 5 micrometers in width can be imaged. SEM can be used to image bacteria, viruses, tissues as well as larger samples like insects. Conventional SEM gives a magnification ranging from 20X to 30,000X and spatial resolution of 50 to 100 nanometers.
Fundamental Principles
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Related Experiment Video

Updated: Jun 15, 2026

Intact Histological Characterization of Brain-implanted Microdevices and Surrounding Tissue
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Different Innovative Laser Implants Characteristics Histomorphometric and SEM-EDX Comparison for In Vivo

Filiberto Mastrangelo1, Marco Cicciù2, Raimondo Quaresima3

  • 1Department of Clinical and Experimental Medicine, University of Foggia, Via Rovelli n. 60, 77100 Foggia, Italy.

Materials (Basel, Switzerland)
|July 12, 2025
PubMed
Summary
This summary is machine-generated.

Innovative laser-treated titanium implants (L1-L2) demonstrated superior bone integration compared to standard sandblasted and acid-etched (SBAE) implants. The L2 surface showed enhanced early osseointegration (EO), suggesting improved long-term clinical outcomes.

Keywords:
SEM-EDX analysisbone quality indexbone-to-implant contactdynamic osseointegration indexlaser titanium implantsosseointegrationsandblasted and acid-etched implantswettability

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Area of Science:

  • Biomaterials Science
  • Dental Implantology
  • Tissue Engineering

Background:

  • Osseointegration is critical for dental implant success.
  • Surface characteristics significantly influence osseointegration.
  • Novel laser treatments offer potential improvements over traditional implant surfaces.

Purpose of the Study:

  • To compare the bone behavior of two laser-treated titanium implant surfaces (L1, L2) against a sandblasted and acid-etched (SBAE) control in an animal model.
  • To evaluate the impact of surface modifications on early and long-term osseointegration.
  • To assess bone-to-implant contact (BIC), dynamic osseointegration index (DOI), and bone quality index (BQI).

Main Methods:

  • Twenty-seven titanium implants were placed in three sheep.
  • Surface analysis included profilometry, contact angle, and EDX.
  • Histological, histomorphometric, and SEM-EDX analyses were performed at 15, 30, and 90 days.
  • Key metrics: BIC, DOI, and BQI (Ca/P ratio).

Main Results:

  • Laser-treated surfaces exhibited distinct profilometric and wettability properties.
  • L2 implants showed significantly higher BIC at 15 and 30 days compared to L1 and SBAE.
  • L2 also demonstrated higher DOI rates during early osseointegration phases.
  • BQI analysis indicated that osseointegration was not complete before loading, with L2 showing better bone quality.

Conclusions:

  • Osseointegration is a dynamic process influenced by implant surface characteristics, particularly during the early osseointegration (EO) phase.
  • The L2 laser-treated surface demonstrated superior bone quantity and quality in the short term.
  • This innovative surface holds promise for achieving enhanced secondary stability and predictable long-term clinical outcomes in dental implantology.