Related Experiment Video
Updated: Sep 16, 2025
06:53
Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
Published on: November 11, 2016
8.4K
Circadian Clock Deregulation and Metabolic Reprogramming: A System Biology Approach to Tissue-Specific Redox
Rossitza Konakchieva1, Mitko Mladenov2,3, Marina Konaktchieva4
1Department of Cell and Developmental Biology, Faculty of Biology, Sofia University "St. Kliment Ohridski", 1164 Sofia, Bulgaria.
International Journal of Molecular Sciences
|July 12, 2025
Summary
Chronic circadian rhythm disruption from modern lifestyles promotes metabolic inflammation and disease. Understanding this link offers new therapeutic strategies for restoring health and preventing chronic conditions.
Area of Science:
- Chronobiology
- Metabolic Health
- Cellular Stress Response
Background:
- Circadian rhythms regulate fundamental cellular processes like metabolism and redox balance.
- Modern lifestyle factors disrupt these rhythms, leading to oxidative stress, metabolic dysfunction, and chronic diseases.
- Circadian misalignment is increasingly linked to impaired proteostasis and metabolic inflammation.
Purpose of the Study:
- To review mechanistic advances linking circadian misalignment to tissue-specific metabolic reprogramming.
- To highlight the interplay between the circadian clock, protein turnover, and redox homeostasis.
- To explore the role of circadian modulation in inflammasome activity and its implications for disease.
Main Methods:
- Review of recent mechanistic studies on circadian biology and metabolic pathways.
- Focus on proteostasis, metabolic inflammation, and inflammasome complex activity.
- Examination of chrono-epigenetics and tissue-specific clock programming.
Main Results:
- Circadian misalignment drives metabolic inflammation and impairs proteostasis.
- A close interdependence exists between the circadian clock and proteasome function.
- Circadian control of inflammasome activity is a potential risk factor for malignancy and metabolic syndrome.
Conclusions:
- Elucidating the circadian biology-metabolic inflammation link is crucial for developing novel therapies.
- Emerging chrono-epigenetics and precision medicine offer new therapeutic avenues.
- Circadian-based interventions like time-restricted feeding and chronopharmacology hold promise for restoring homeostasis.
Keywords:
adipose tissuechrono-epigeneticscircadian systeminflammasome activationlivermetabolic reprogrammingproteostasisredox homeostasisMore Related Videos
Related Concept Videos
02:19Circadian Rhythms and Gene Regulation
4.2K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.2K
01:19Regulation of Metabolism
9.9K
Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
9.9K
01:27Redox Reactions
195
Redox reactions are vital biochemical processes that underpin energy metabolism in cells. These reactions involve the transfer of electrons between molecules, occurring in tandem as oxidation and reduction. Oxidation refers to the loss of electrons, while reduction denotes their gain. This coupling ensures the seamless flow of electrons through metabolic pathways. For example, in bacterial metabolism, glucose undergoes oxidation to carbon dioxide, while oxygen is simultaneously reduced to...
195
01:28Global Regulatory Systems
82
Global regulatory systems in bacteria enable rapid and coordinated responses to environmental changes by integrating sensory inputs with gene expression, ensuring efficient adaptation to fluctuating conditions. Key global regulatory mechanisms include regulons, two-component systems, sigma factors, and secondary messengers.Regulons and Global RegulatorsA regulon is a collection of genes and operons controlled by a common global regulator. These regulators enable bacteria to prioritize resource...
82
01:15Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
131
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
131
02:45Biological Clocks and Seasonal Responses
38.7K
The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
38.7K