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[Comparative analysis of the malignancy of tumors in mice induced by 20-methylcholanthrene]
Abstract:
Malignancy of 13 cell cultures cultivated in vitro was studied. 11 cultures were induced by subcutaneous injection of 20-methylcholanthrene to 3 lines of mice. The malignancy was studied by transplantability, growth rate and metastasis formation after subcutaneous injection of a various cell number into normal and sublethally irradiated syngenic mice. A convenient model for studying the significance of certain immunological properties of tumour cells in determination of the malignancy was obtained.