Chromosome-Contiguous Reference Genome for Spirometra to Underpin Future Discovery Research

Area of Science:

• Parasitology
• Genomics
• Zoonotic Diseases

Background:

• Sparganosis is a neglected food- and water-borne zoonotic disease caused by Spirometra tapeworms.
• Over 1600 human cases are reported, primarily in Asia, but its clinical significance is likely underestimated.
• Current treatments (mebendazole, praziquantel) are often ineffective, necessitating novel interventions.

Purpose of the Study:

• To assemble and annotate the first high-quality genome of Spirometra from Australia.
• To provide a valuable resource for molecular investigations of Spirometra species.
• To aid in designing new intervention tools against sparganosis.

Main Methods:

• Advanced DNA sequencing and bioinformatic approaches were utilized.
• Chromosome-level contiguity and a curated gene set were achieved for the Spirometra genome.
• The study focused on an isolate from Australia.

Main Results:

• The first high-quality, chromosome-level genome assembly of Spirometra was successfully produced.
• A curated gene set was established for the Spirometra genome.
• This resource is now available for further research.

Conclusions:

• The high-quality Spirometra genome is a crucial resource for understanding the parasite's biology.
• This genomic data will support the development of new diagnostic and therapeutic strategies for sparganosis.
• Intervention against sparganosis in companion animals and humans can be advanced through this research.