Related Experiment Video
Updated: Sep 16, 2025
09:56
A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy
Published on: February 21, 2025
811
Stem Cell for Cancer Immunotherapy: Current Approaches and Challenges.
Zainab Alali1, Umme Tamanna Ferdous2, Alexis Nzila1,3
1Department of Bioengineering, King Fahd University of Petroleum & Minerals, 31261, Dhahran, Saudi Arabia.
Stem Cell Reviews and Reports
|July 12, 2025
Summary
Stem cell immunotherapy offers novel cancer treatment strategies by engineering immune cells and modifying the tumor microenvironment. Ongoing research addresses challenges to enhance safety and efficacy for personalized cancer therapies.
Area of Science:
- Oncology
- Immunology
- Regenerative Medicine
Background:
- Stem cell-based immunotherapy is a rapidly advancing field in cancer treatment.
- It utilizes the immune system to target and eliminate cancer cells.
- Various stem cell types, including hematopoietic, mesenchymal, and induced pluripotent stem cells (IPSCs), are being explored.
Purpose of the Study:
- To review stem cell functionalities in cancer immunotherapy.
- To discuss clinical applications and challenges of stem cell technology in cancer treatment.
- To highlight advancements and future trends in stem cell-based cancer therapies.
Main Methods:
- Review of current literature on stem cell applications in cancer immunotherapy.
- Exploration of stem cell roles in modifying the tumor microenvironment (TME).
- Analysis of engineered immune cells (CAR-T, NK cells) and drug delivery systems.
Main Results:
- Stem cells can modify the TME and support engineered immune cells like CAR-T and NK cells.
- Clinical applications include improved cancer immunotherapies and targeted drug delivery to solid tumors.
- Challenges include safety, tumor immune evasion, manufacturing, and regulatory hurdles.
Conclusions:
- Advancements like CRISPR gene editing and targeted delivery systems are overcoming current challenges.
- Personalized stem cell therapies and combination treatments show promise for increased efficacy.
- Stem cell immunotherapy holds significant potential for future cancer treatment paradigms.
More Related Videos
Related Concept Videos
01:27Tumor Immunotherapy
664
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
664
01:30Cancer Vaccines
517
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
517
01:21Stem Cell Therapy for Tissue Regeneration
4.2K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.2K
02:40Cancer Stem Cells and Tumor Maintenance
5.0K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
5.0K
01:22iPS Cell Differentiation
2.8K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
2.8K
01:06Induced Pluripotent Stem Cells
4.4K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
Somatic...
4.4K