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Exploring Schiff base bromhexine derivatives: study on synthesis, characterization, biological assays, molecular
Zarmeena Yasmeen1, Mohsin Abbas Khan1,2, Anum Masood3
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Pakistan.
Future Medicinal Chemistry
|July 12, 2025
Summary
Newly synthesized bromhexine Schiff base derivatives show potential as antiviral and antioxidant agents. Molecular docking suggests BM6 and BM7 are promising candidates for inhibiting α-amylase and α-glucosidase, indicating therapeutic potential.
Area of Science:
- Medicinal Chemistry
- Drug Design
- Pharmacology
Background:
- Schiff bases are crucial in drug design due to their diverse pharmacological applications.
- Bromhexine derivatives are being explored for enhanced therapeutic properties.
Purpose of the Study:
- To synthesize and characterize novel Schiff base derivatives of bromhexine.
- To evaluate the antiviral, antioxidant, and enzyme inhibition activities of these derivatives.
- To identify potential lead compounds for therapeutic agent development.
Main Methods:
- Synthesis and characterization using Infrared (IR) and Nuclear Magnetic Resonance (1H NMR, 13C NMR) spectroscopy.
- Antiviral screening via hemagglutination inhibition assay.
- Antioxidant activity assessment using the DPPH method.
- Molecular docking studies against α-amylase and α-glucosidase.
Main Results:
- Compound BM9 exhibited potent antiviral activity (IC50 = 3.01 ± 1.70).
- Molecular docking identified BM6 and BM7 as strong inhibitors of α-amylase and α-glucosidase.
- The synthesized derivatives demonstrated significant antioxidant potential.
Conclusions:
- The novel bromhexine Schiff base derivatives show promise as multifunctional therapeutic agents.
- BM9, BM6, and BM7 are identified as lead compounds for further drug development.
- This research highlights the potential of Schiff bases in creating new antiviral and enzyme-inhibiting drugs.
