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Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
Published on: June 1, 2012
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Nanotechnology-enhanced transdermal systems for infectious diseases
Swati Udugade1, Babaso V Udugade2, Sanket R Patil3
1Krishna Institute of Pharmacy, Karad, India.
Current Opinion in Pharmacology
|July 12, 2025
Summary
Nanotechnology-enhanced transdermal drug delivery systems (NETS) offer improved treatment for infectious diseases by enhancing drug delivery. While NETS show promise, challenges in toxicity and regulation need further research for clinical application.
Area of Science:
- Pharmaceutical Sciences
- Nanomedicine
- Infectious Diseases
Background:
- Traditional drug delivery faces challenges with skin penetration and bioavailability.
- Infectious diseases require effective and targeted therapeutic strategies.
- Nanotechnology offers novel solutions for overcoming drug delivery barriers.
Purpose of the Study:
- To review nanotechnology-enhanced transdermal drug delivery systems (NETS) for infectious diseases.
- To explore the mechanisms, advantages, and limitations of NETS.
- To highlight future research and clinical applications of NETS.
Main Methods:
- Review of literature on nanotechnology-based transdermal systems.
- Analysis of nanoparticle-based drug delivery mechanisms (lipid-based, polymeric, dendrimers).
- Examination of efficacy and safety data for NETS in infectious disease models.
Main Results:
- NETS significantly improve drug penetration, stability, and bioavailability.
- Lipid-based nanoparticles, polymeric nanoparticles, and dendrimers facilitate efficient drug transport and controlled release.
- NETS demonstrate enhanced therapeutic efficacy and reduced side effects for bacterial, viral, and fungal infections.
Conclusions:
- NETS represent a promising approach for treating infectious diseases.
- Further research is needed to address challenges in toxicity, stability, and regulatory approval.
- NETS hold potential for future clinical applications in combating infections.
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