Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of DNA Repair02:25

Overview of DNA Repair

7.8K
7.8K
Nucleotide Excision Repair01:38

Nucleotide Excision Repair

3.8K
DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
3.8K
Base-pairing and DNA Repair02:27

Base-pairing and DNA Repair

65.1K
65.1K
Replication in Eukaryotes01:29

Replication in Eukaryotes

14.7K
In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
14.7K
DNA Damage can Stall the Cell Cycle02:37

DNA Damage can Stall the Cell Cycle

9.3K
In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
9.3K
Fixing Double-strand Breaks02:04

Fixing Double-strand Breaks

3.4K
3.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Internal Microbiota Guided Stage Selection in Two Swine-Manure Bioconversion Flies for Feed-Protein Harvest.

Insects·2026
Same author

Climate Toxicity in Cancer Care: A Concept Analysis.

International journal of nursing practice·2026
Same author

Ectopic FGFR1 Increases Intracellular Pool of Cholesterol in Prostate Cancer Cells.

International journal of molecular sciences·2026
Same author

Spermidine-functionalized Janus hydrogel microneedles inhibit ferroptosis and promote healing of oral ulcers.

Bioactive materials·2026
Same author

Current update on toll-like receptors and prostate cancer: a decade of progress and emerging insights.

Frontiers in immunology·2026
Same author

Metabolic support protects mucosa from ferroptosis in radiation-induced mucositis.

Nature communications·2025

Related Experiment Video

Updated: Sep 15, 2025

Author Spotlight: Decoding DNA Repair by Extrachromosomal NHEJ Assay and HR Assays
09:29

Author Spotlight: Decoding DNA Repair by Extrachromosomal NHEJ Assay and HR Assays

Published on: February 2, 2024

2.6K

Decoding DNA repair regulation across human lifespan variability.

Yunjia Tang1, Dekai Zhang1, Kaiyan Wang1

  • 1Shanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.

Ageing Research Reviews
|July 12, 2025
PubMed
Summary

DNA repair mechanisms are crucial for genetic stability and aging. This review explores human lifespan diversity to understand DNA repair

Keywords:
AgingDNA repairLifespan diversityLongevityProgeroid syndromes

More Related Videos

Characterizing DNA Repair Processes at Transient and Long-lasting Double-strand DNA Breaks by Immunofluorescence Microscopy
08:31

Characterizing DNA Repair Processes at Transient and Long-lasting Double-strand DNA Breaks by Immunofluorescence Microscopy

Published on: June 8, 2018

9.2K
Author Spotlight: Visualizing Single-Stranded DNA During DNA Repair for Therapeutic Insights
08:30

Author Spotlight: Visualizing Single-Stranded DNA During DNA Repair for Therapeutic Insights

Published on: December 22, 2023

2.7K

Related Experiment Videos

Last Updated: Sep 15, 2025

Author Spotlight: Decoding DNA Repair by Extrachromosomal NHEJ Assay and HR Assays
09:29

Author Spotlight: Decoding DNA Repair by Extrachromosomal NHEJ Assay and HR Assays

Published on: February 2, 2024

2.6K
Characterizing DNA Repair Processes at Transient and Long-lasting Double-strand DNA Breaks by Immunofluorescence Microscopy
08:31

Characterizing DNA Repair Processes at Transient and Long-lasting Double-strand DNA Breaks by Immunofluorescence Microscopy

Published on: June 8, 2018

9.2K
Author Spotlight: Visualizing Single-Stranded DNA During DNA Repair for Therapeutic Insights
08:30

Author Spotlight: Visualizing Single-Stranded DNA During DNA Repair for Therapeutic Insights

Published on: December 22, 2023

2.7K

Area of Science:

  • Genetics
  • Molecular Biology
  • Aging Research

Background:

  • DNA repair is vital for maintaining genetic integrity and is linked to aging and longevity.
  • Research on DNA repair and aging often uses animal models, which may not fully represent human biology.
  • Human lifespan shows significant variability, offering a unique model for studying aging regulation.

Purpose of the Study:

  • To review the molecular basis of DNA repair in relation to human lifespan.
  • To explore how variations in DNA repair pathways influence aging trajectories.
  • To identify potential therapeutic targets for longevity by modulating DNA repair.

Main Methods:

  • Integration of current research on DNA repair mechanisms.
  • Comparative analysis of human aging trajectories and associated DNA repair profiles.
  • Review of studies focusing on genetic factors influencing lifespan and DNA repair efficiency.

Main Results:

  • Human aging rates vary significantly, correlating with differences in DNA repair capacities.
  • Specific DNA repair pathways show differential involvement in extreme longevity and progeroid syndromes.
  • Insights into the molecular underpinnings of lifespan regulation through DNA repair.

Conclusions:

  • Human lifespan diversity provides a valuable framework for understanding aging at a molecular level.
  • Targeted modulation of DNA repair pathways holds promise for developing pro-longevity therapies.
  • Further research integrating human genetic data and DNA repair mechanisms is warranted.