Meningiomas Following the Previous Cancer Therapies: Brief Report

Ionizing radiation is known to induce brain tumors such as meningiomas and gliomas over a time. Similar tumorogenic effects have been described with chemotherapeutic agents also. However, the literature is sparse regarding this entity. There has been some new understanding derived from the molecular studies regarding the mechanism of such tumorogenesis. To highlight such updates in the current knowledge is the objective. Two patients treated for malignancy in their childhood developed meningiomas in later part of their life. This highlights the possibility of developing meningiomas or other endocrinal tumors following the treatment for malignancy at a younger age. The need for long-term follow-up of these patients is the highlight of the report. Both the meningiomas were successfully removed surgically with favorable clinical outcomes. However, prevalence and risk projection need to be identified to plan the clinical management and long-term follow-up. Though meningiomas are known to be induced by previous radiotherapy, the exact mechanisms are not yet clear. Recent research indicates the genetic abnormalities and molecular abnormalities that can induce or evolve Meningiomas following radiotherapy. These tumors seem to form a distinctly different group molecularly and can be aggressive clinically. Understanding biomolecular pathogenesis is important to manage such patients adequately.