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Related Experiment Video

Updated: Sep 15, 2025

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
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Association between systemic inflammatory markers and depression: A meta-analysis.

Xiaowei Jiang1, Jiahui Pei1, Houze Diao1

  • 1Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, 1163 Xinmin Avenue, Changchun 130021, PR China.

General Hospital Psychiatry
|July 13, 2025
PubMed
Summary
This summary is machine-generated.

This study found higher levels of neutrophil-to-lymphocyte ratio (NLR) and systemic immune-inflammation index (SII) in individuals with depression. NLR shows potential as a diagnostic marker for depression.

Keywords:
DepressionInflammatory markersMeta-analysisNLRSII

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Area of Science:

  • Medical research
  • Immunology
  • Psychiatry

Background:

  • Controversial findings exist regarding associations between systemic inflammation markers (SII, NLR, SIRI, AISI, NLPR) and depression.
  • Inflammation's role in depression requires further clarification.

Purpose of the Study:

  • To determine the association between systemic inflammatory markers and depression prevalence.
  • To evaluate the diagnostic effectiveness of these markers for depression.

Main Methods:

  • A meta-analysis of 41 studies (205,438 participants) was conducted.
  • Searched databases: Web of Science, PubMed, Cochrane Library, EMBASE.
  • Assessed differences in SII, NLR, SIRI, AISI, and NLPR using OR, SMD, 95% CI; performed subgroup, sensitivity, and diagnostic effectiveness analyses.

Main Results:

  • Depressed individuals had significantly higher NLR and SII levels compared to controls.
  • NLR demonstrated effectiveness as a diagnostic marker for depression (AUC=0.70).
  • SII showed less effectiveness as a diagnostic marker (AUC=0.37).

Conclusions:

  • Inflammation is associated with depression, supporting the hypothesis.
  • NLR and SII show potential as predictors of depression.
  • Further research is needed for SIRI, AISI, and NLPR due to limited studies.