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Targeting fructose metabolism for cancer therapy
Qing Zhao1, Wen-Lian Chen2, Gerry Melino3
1Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China.
Abstract:
Cancer cells frequently rewire their metabolism to support rapid proliferation and invasion. Our analysis of the most lethal cancers in 2022 reveals a prominent association with dysregulated fructose metabolism. Fructose serves as a crucial alternative energy substrate under nutrient-deprived conditions, promoting the Warburg effect and thereby facilitating tumor growth and metastasis. Moreover, aberrant fructose utilization activates oncogenic mTORC1 signaling, suppresses anti-tumor immune responses, and facilitates tumor progression. Targeting key enzymes and transporters in fructose metabolism presents a promising therapeutic avenue to disrupt tumor bioenergetics and signaling pathways, potentially improving treatment efficacy and patient outcomes.
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