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Updated: Sep 15, 2025

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
Published on: October 15, 2019
Influence of gut microbiota on systemic immune responses and cancer immunotherapy
Swathi P Murakonda1, Sahasra Balusu2, Haritha Chava3
1Sri Rajiv Gandhi College of Dental Sciences & Hospital, Bengaluru, Karnataka, India.
Abstract:
The gut microbiota is increasingly being recognized as a key player in the onset and progression of several human diseases, including malignancies. Recent research has shed light on the complex relationships between the gut microbiome and the effectiveness of cancer immunotherapy. Gaining a thorough understanding of how the gut microbiota influences immune responses during cancer treatments is critical for medical advancements. This review aims to delve into the intricate interactions between gut microbiota, the systemic immune system, and cancer immunotherapy. Additionally, as the gut microbiota can contribute to immune-related adverse effects, we explored possible interventions to alleviate these side effects and reviewed microbiota-targeted strategies that could enhance the success of cancer immunotherapies.
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