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Updated: Sep 15, 2025

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The Establishment of a Murine Mandibular Molar Extraction Socket Healing Model
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The Periodontal Benefits of Alveolar Ridge Augmentation With Xenograft Following Third Molar Extraction: A Randomised
Su Sheng Quach1, Nigel Johnson1,2, Raahib Dudhia1
1School of Dentistry, The University of Queensland, Herston, Queensland, Australia.
Journal of Clinical Periodontology
|July 13, 2025
Summary
Deproteinised bovine bone mineral with collagen (DBBM-C) grafting during third molar extraction did not significantly enhance periodontal healing at the adjacent second molar site. Clinical outcomes showed no significant differences between grafted and non-grafted extraction sites after six months.
Area of Science:
- Periodontal regeneration
- Oral surgery
- Biomaterials in dentistry
Background:
- Third molar extraction often leads to periodontal defects at adjacent teeth.
- Grafting materials are explored to improve healing in extraction sockets.
- Deproteinised bovine bone mineral with collagen (DBBM-C) is a commonly used bone graft substitute.
Purpose of the Study:
- To assess the efficacy of DBBM-C grafting in promoting periodontal healing.
- To evaluate the impact of DBBM-C on the distal aspect of the second molar (D2M) following third molar extraction.
- To compare linear and volumetric bone fill at the D2M site with and without grafting.
Main Methods:
- A randomized controlled trial involving 28 patients and 42 extraction sites.
- Test group received DBBM-C grafting during extraction; control group received extraction alone.
- Periodontal healing assessed using linear and volumetric cone beam computed tomography (CBCT) at 6 months.
Main Results:
- Significant healing observed in both groups based on linear and volumetric measurements.
- No statistically significant differences were found between the DBBM-C grafted group and the control group.
- Healing at the disto-lingual aspect of the second molar showed variability.
Conclusions:
- DBBM-C grafting during third molar extraction did not demonstrate a significant benefit for periodontal healing at the D2M.
- Further research may be needed to explore alternative grafting strategies or patient selection criteria.
- The study was registered under ACTRN12620000497909.

