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Updated: Sep 15, 2025
The Establishment of a Murine Mandibular Molar Extraction Socket Healing Model
Published on: January 13, 2023
The Periodontal Benefits of Alveolar Ridge Augmentation With Xenograft Following Third Molar Extraction: A Randomised
Su Sheng Quach1, Nigel Johnson1,2, Raahib Dudhia1
1School of Dentistry, The University of Queensland, Herston, Queensland, Australia.
Aim:
To evaluate the effect of deproteinised bovine bone mineral with collagen (DBBM-C) grafting on periodontal healing at the distal aspect of the second molar (D2M) during adjacent third molar extraction.
Material And Methods:
Forty-two sites in 28 patients were randomly allocated into two groups. The test group (18 sites) received DBBM-C grafting during extraction, whereas the control group (24 sites) received extraction alone. The patients were reviewed 6 months postoperatively, and the D2M and extraction sites were evaluated by both linear and volumetric cone beam computed tomography measurements.
Results:
Nine patients dropped out (14 sites) and two patients were excluded (4 sites), leaving a total of 17 patients (24 sites) who were reviewed after 6 months. Both groups showed significant healing when examining the linear measurements (except at the disto-lingual aspect of the second molar) and the defined volumes of interest. There were, however, no significant differences between the groups in the linear or volumetric outcome analyses.
Conclusions:
Within the limitations of the study, the use of DBBM-C during third molar extraction did not improve periodontal healing at the D2M. This trial was registered in April 2020 in the Australian New Zealand Clinical Trials Registry under code ACTRN12620000497909 (https://anzctr.org.au/Trial/Registration/TrialReview.aspx?ACTRN=12620000497909).
