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Advanced Injectable Human-Derived Microgels for Improved Cell Delivery and Tissue Regeneration.

Maria C Mendes1, Sara C Santos1,2, Catarina A Custódio1,2

  • 1Department of Chemistry, CICECO - Aveiro Institute of Materials, University of Aveiro, Campus Universitário de Santiago, Aveiro, 3810-193, Portugal.

Advanced Healthcare Materials
|July 14, 2025
PubMed
Summary

Researchers developed injectable human protein microgels for cell therapy. These microgels protect cells, promote migration, and can be magnetically controlled, offering a promising solution for cell delivery challenges.

Keywords:
deliveryenzyme‐mediated cell releasehuman‐derived microgelsinjectable systemsmagnetic nanoparticles

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Cell delivery therapies face challenges in cell viability and retention post-injection.
  • Existing hydrogels often use animal-derived materials (immunogenicity) or synthetic polymers (poor cell adhesion).

Purpose of the Study:

  • To develop injectable, human protein-derived microgels for enhanced cell delivery.
  • To create a cell carrier that supports cell viability and promotes controlled cell migration.

Main Methods:

  • Fabrication of methacryloyl platelet lysate microgels using a solvent-free method on superhydrophobic surfaces via light irradiation.
  • Incorporation of collagenase to facilitate enzyme-mediated cell migration.
  • Assessment of injectability, cell viability, morphology, and defect-filling capacity in porcine tissue.
  • Modification with magnetic nanoparticles for spatial control.

Main Results:

  • Human protein-derived microgels successfully sustained cell viability and promoted mesenchymal stem cell migration.
  • Enzyme-mediated degradation allowed controlled outward cell movement without compromising viability.
  • Microgels demonstrated injectability, preserved morphology, and effectively filled irregular tissue defects.
  • Magnetic nanoparticle incorporation enabled external magnetic field control.

Conclusions:

  • Injectable human protein microgels are a viable platform for cell delivery, overcoming limitations of current therapies.
  • The developed microgels support cell viability, enhance migration, and offer tunable properties for personalized cell therapies.
  • The technology shows potential for improved therapeutic outcomes in regenerative medicine and tissue repair.