ALA Alleviates Liver Damage in Septic Mice Through PI3K/AKT Signaling Pathway

Sepsis is a life-threatening systemic inflammatory response syndrome that arises from infection and frequently progresses to multi-organ dysfunction, with liver injury being a particularly significant manifestation. Alpha-lipoic acid (ALA), renowned for its potent antioxidant and anti-inflammatory properties, has demonstrated promising protective effects in sepsis. The present study aims to investigate the protective effects of ALA on liver damage in septic mice by modulating the PI3K/AKT signaling pathway, thereby providing novel therapeutic strategies for the treatment of sepsis. The cecal ligation and puncture (CLP) model was employed to induce sepsis in mice, and both ALA-treated and control groups were established. The protective effects of ALA were evaluated through the detection of PI3K/AKT signaling pathway-related protein expression, apoptosis in liver cells, and liver function indicators. Additionally, Western blotting and immunohistochemistry were utilized to further validate ALA's regulatory impact on the PI3K/AKT signaling pathway. The study revealed that ALA significantly enhanced the activation of the PI3K/AKT signaling pathway, reduced apoptosis in liver cells of septic mice, and improved liver function indicators. Moreover, liver tissue pathology in the ALA-treated group was markedly less severe compared to that in the control group, indicating its effective hepatoprotective action. These findings demonstrate that ALA effectively alleviates liver damage in septic mice by promoting the PI3K/AKT signaling pathway, highlighting its potential clinical value. This research provides new targets and insights for the development of therapeutic strategies for sepsis.