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Diffuse Tongue Enlargement Related to Amyloidosis: A Case Report
Abdulaziz Alwakeel1, Mohamed Rahoof Arakkalvettath2, Samia Nawaz3
1Department of Oral Medicine and Pathology, Tabuk Specialist Dental Center, Tabuk Health Cluster, Tabuk, Saudi Arabia.
Journal of Pharmacy & Bioallied Sciences
|July 14, 2025
Summary
This case report highlights oral amyloidosis, a rare condition causing diffuse tongue enlargement. Early diagnosis through clinical examination and biopsy is crucial for effective management of this systemic or localized disease.
Area of Science:
- Oral Medicine
- Pathology
Background:
- Amyloidosis, a condition involving protein deposits, can manifest systemically or locally.
- The head and neck region, particularly the tongue and larynx, are common sites for amyloidosis.
Observation:
- An 82-year-old male presented with tongue swelling, heaviness, and difficulty eating.
- Clinical examination revealed diffuse tongue enlargement with multiple yellow nodules on the lateral borders.
Findings:
- Histopathological evaluation confirmed amyloid material deposition in the submucosal area.
- Congo red staining was positive, supporting the diagnosis of oral amyloidosis.
Implications:
- This case underscores the importance of considering oral amyloidosis in patients with unexplained tongue enlargement.
- Prompt diagnosis and appropriate referral are essential for managing this condition and determining the underlying systemic cause.
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