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Pediatric Staphylococcal Scalded Skin Syndrome Complicated by Methicillin-Resistant Staphylococcus Aureus and Steroid

Ujjwal Kumar Jha1, Ajay Kumar Yadav2

  • 1Grande International Hospital, Dhapasi, Kathmandu, Nepal.

JNMA; Journal of the Nepal Medical Association
|July 14, 2025
PubMed

Insights

Staphylococcal Scalded Skin Syndrome (SSSS) complicated by Methicillin-Resistant Staphylococcus aureus (MRSA) requires prompt diagnosis and targeted antibiotic therapy. This case report highlights successful management through culture-guided treatment in a pediatric patient.

Area of Science:

  • Pediatric Dermatology
  • Infectious Diseases
  • Clinical Case Reports

Background:

  • Staphylococcal Scalded Skin Syndrome (SSSS) is a blistering skin disorder caused by exfoliative toxins from Staphylococcus aureus.
  • It predominantly affects infants and children, presenting a diagnostic challenge due to its varied clinical manifestations.

Observation:

  • A pediatric patient presented with a two-week history of worsening pruritic vesiculobullous eruptions.
  • Initial treatments with topical steroids and antibiotics were ineffective, indicating a potential resistant pathogen.
  • Wound cultures revealed heavy growth of Methicillin-Resistant Staphylococcus aureus (MRSA).

Findings:

  • The patient's SSSS was complicated by MRSA infection, necessitating a revised therapeutic strategy.
  • A change in antibiotic regimen, guided by culture and sensitivity testing, led to significant clinical improvement.
  • This case demonstrates the critical role of microbiological diagnostics in managing SSSS with resistant strains.

Implications:

  • Accurate and timely diagnosis is crucial for effective SSSS management, especially in cases involving MRSA.
  • Culture and sensitivity testing are vital for selecting appropriate antibiotic therapy against resistant pathogens.
  • A multidisciplinary approach is recommended for optimizing treatment outcomes in complex pediatric dermatological conditions.

Keywords:
MRSAStaphylococcalcase reportskin

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