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Updated: Sep 15, 2025
Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
Published on: May 10, 2024
Additional considerations on a combination of inflammatory markers and scoring systems for early severity
1Department of Gastroenterology and Hepatology, The First Medical Center, Chinese PLA General Hospital, Beijing 100853, China.
Abstract:
A recent single-center retrospective study proposed novel combinations of hematological parameters and scoring systems for predicting severe acute pancreatitis. While these combinations showed promising predictive performance, several limitations warrant consideration, including the lack of calibration, the absence of key inflammatory markers such as procalcitonin, and practical challenges in integrating these models into routine clinical workflows. To improve predictive accuracy and clinical applicability, prospective validation and the inclusion of additional variables are recommended.
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