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Associations between squalene epoxidase gene polymorphisms and obesity
Jia-Qing Yu1, Feng-Xia Wang1, Shuai Liu1
1The First Affiliated Hospital of Xinjiang Medical University, Wulumuqi, Xinjiang, China.
Peerj
|July 14, 2025
Summary
Genetic variations in the squalene epoxidase (SQLE) gene, specifically rs10104486 and rs2288312, are linked to obesity. The CC genotype of rs10104486 increases obesity risk in young individuals.
Area of Science:
- Genetics
- Metabolism
- Obesity Research
Background:
- Squalene epoxidase (SQLE) is a critical enzyme in cholesterol synthesis.
- Understanding SQLE's role is key to managing cholesterol metabolism.
Purpose of the Study:
- To investigate the association between SQLE gene single nucleotide polymorphisms (SNPs) and obesity.
- To identify specific SQLE gene variants linked to obesity risk in a young population.
Main Methods:
- Analyzed 1,045 participants, divided into obese and control groups.
- Extracted deoxyribonucleic acid (DNA) and measured blood biochemical markers.
- Performed statistical analyses to assess associations between SQLE SNPs and obesity.
Main Results:
- The CC genotype of SQLE SNP1 (rs10104486) showed a significant association with obesity.
- Significant differences in genotype and allele frequencies for rs10104486 and rs2288312 were observed between groups.
- Recessive models for both SNPs indicated a statistically significant link to obesity.
Conclusions:
- SQLE gene polymorphisms rs10104486 and rs2288312 correlate with obesity in young individuals.
- Carrying the C allele of rs10104486 increases the likelihood of developing obesity.
- The CC genotype of rs10104486 is identified as a predisposing factor for obesity.
Keywords:
Blood lipid metabolismBody mass indexGeneGene polymorphismsHealth preventionObesitySqualene epoxidaseYouthMore Related Videos
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