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Primary Hepatic Leiomyosarcoma: A Case Series Highlighting a Rare Malignancy
Divya Khosla1, Treshita Dey1, Rakesh Kapoor1
1Department of Radiotherapy and Oncology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Journal of Clinical and Experimental Hepatology
|July 14, 2025
Summary
Primary hepatic leiomyosarcoma (PHLMS) is a rare liver cancer. This case series highlights diagnostic challenges and poor prognosis, emphasizing surgery as key treatment.
Area of Science:
- Oncology
- Gastroenterology
- Pathology
Background:
- Primary hepatic leiomyosarcoma (PHLMS) is an exceptionally rare liver malignancy.
- Few cases are documented, making diagnosis and management challenging.
Observation:
- This study details five PHLMS cases managed at a single institute.
- Patients presented with non-specific symptoms like abdominal pain and jaundice.
- Imaging revealed liver space-occupying lesions, necessitating histopathology for definitive diagnosis.
Findings:
- Histopathology showed spindle cells in fascicles, high mitotic rates, and necrosis.
- Only one patient underwent surgical resection; others received palliative chemotherapy or supportive care.
- Prognosis for PHLMS is generally poor, even with aggressive treatment.
Implications:
- Surgical resection is crucial for radical PHLMS treatment.
- This series offers insights into diagnosing and managing this rare liver tumor.
- Further research is needed to improve PHLMS patient outcomes.
