Related Experiment Video

Updated: Sep 15, 2025

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies
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Cancer-Associated PIK3R1 Genetic Aberrations and Precision Medicine

Huan Xie1,2, Yirong Li1,2, Xinran Li1,2

  • 1Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.

International Journal of Medical Sciences
|July 14, 2025
PubMed

Insights

The PIK3R1 gene, a tumor suppressor, is frequently altered in cancer. Its aberrations promote tumorigenesis and progression, impacting prognosis and offering targets for precision medicine.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • The PIK3R1 gene encodes the p85α regulatory subunit of class IA PI3K.
  • PIK3R1 acts as a tumor suppressor by regulating p110 catalytic activity and enhancing PTEN phosphatase activity.
  • Alterations in PIK3R1 are linked to poor cancer prognosis and tumorigenesis via the PI3K/AKT/mTOR pathway.

Purpose of the Study:

  • To review the cancer-promoting effects of PIK3R1 gene aberrations across major cancer types.
  • To elucidate the underlying mechanisms of PIK3R1-mediated tumorigenesis.
  • To discuss targeted therapies for PIK3R1 aberrations in precision medicine.

Main Methods:

  • Literature review of studies on PIK3R1 gene aberrations in cancer.
  • Analysis of mechanisms by which PIK3R1 mutations, copy number variations, and epigenetic alterations contribute to cancer.
  • Synthesis of information on targeted therapeutic strategies.

Main Results:

  • PIK3R1 aberrations, including mutations and copy number variations, are prevalent in various cancers.
  • These aberrations promote tumorigenesis and progression by dysregulating the PI3K/AKT/mTOR pathway.
  • Distinct mechanisms underlie the cancer-promoting effects of different types of PIK3R1 alterations.

Conclusions:

  • PIK3R1 plays a critical role in cancer development and progression.
  • Understanding PIK3R1 aberrations is crucial for developing effective targeted therapies.
  • Targeting PIK3R1 alterations holds promise for advancing precision oncology.
Keywords:
PIK3R1copy number variationepigeneticmutation

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