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Pd-Catalyzed C-H Functionalization/Annulation of 2-Aryl-1,3-dicarbonyls with Vinylcyclopropanes: Merging C-H and C-C
Sajal Roy1, Sharajit Saha1, Hemanga Bhattacharyya1
1Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati 781039, India.
Abstract:
Pd-catalyzed enol-directed cascade C-H functionalization and annulation of 2-aryl-1,3-dicarbonyls have been developed using vinylcyclopropanes as a coupling partner. Utilization of an intrinsic weak chelating group, C-C/C-O bond formation, substrate scope, functional group tolerance, subsequent hydrogenolysis, and hydrogenation of products to furnish alkylated 2-aryl-1,3-dicarbonyls and late-stage product modifications are the important practical features.
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