Efficacy of non-invasive photobiomodulation for congenital color vision deficiency: A randomized controlled trial

Congenital color vision deficiency (CVD) is a prevalent ophthalmic condition for which effective therapeutic interventions remain limited. This study evaluated the efficacy of photobiomodulation (PBM) therapy in individuals with congenital CVD.

A randomized, single-blind, controlled clinical trial was conducted involving 80 participants diagnosed with red-green CVD. Participants were randomly assigned to either a PBM treatment group or a control group. Color vision performance was assessed at baseline, and after 1, 2, and 4 weeks of intervention. Statistical analyses were conducted using the Kruskal-Wallis test with Dunn's post hoc test for multiple comparisons.

Color vision recognition ability demonstrated a statistically significant improvement in the PBM treatment group compared to the control group across various parameters (p < 0.05).

Non-invasive PBM therapy significantly enhances color vision in individuals with congenital CVD, with particularly notable improvements observed in those with green CVD.