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Updated: Sep 15, 2025

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The Role of Platelet microRNAs in Cancer
I A Dremuk1, A N Sveshnikova2, E V Shamova1
1Institute of Biophysics and Cell Engineering, Minsk, Belarus.
Hamostaseologie
|July 14, 2025
Summary
Platelets and their microRNAs are crucial in cancer progression. This review explores platelet microRNAs
Area of Science:
- Oncology
- Hematology
- Molecular Biology
Background:
- Platelets are increasingly recognized for their significant role in cancer progression.
- MicroRNAs within platelet microvesicles are implicated in various cancer stages.
- These microRNAs show potential as diagnostic and prognostic biomarkers for cancer.
Purpose of the Study:
- To review current research on platelet-cancer interactions.
- To summarize the role of platelet microRNAs in cancer development.
- To highlight the potential for future research and therapeutic development.
Main Methods:
- Literature review of current research on platelet-cancer interactions.
- Analysis of studies focusing on microRNAs in platelet microvesicles.
- Synthesis of findings regarding the function of platelet microRNAs in carcinogenesis.
Main Results:
- Platelet microRNAs regulate key cancer processes like proliferation, apoptosis, metastasis, and angiogenesis.
- The dual roles of platelet microRNAs in carcinogenesis present a complex picture.
- Platelet microRNAs are involved in epithelial-mesenchymal transition.
Conclusions:
- Platelet microRNAs are pivotal in cancer development and progression.
- Understanding platelet microRNA functions offers promising avenues for cancer research and therapeutics.
- Further investigation into platelet-cancer interactions is warranted.
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